MPTflex CARS Multiphoton Tomography
The MPTflex CARS tomograph is a CE-certified patented medical imaging system based on two-photon excited autofluorescence (AF) and an add-on module for Coherent Anti-Stokes Raman Scattering (CARS).
The endogenous fluorescent biomolecules NAD(P)H, flavins, porphyrins, elastin, keratin, and melanin as well as non-fluorescent biomolecules like water and lipids can be imaged within seconds and with submicron resolution. The extracellular matrix protein collagen can be detected by its second harmonic generation (SHG). The signals are induced by two femtosecond near infrared laser beams that are guided through an optical arm to a flexible scan/detection head. AF, SHG and CARS signals are recorded by multichannel PMT detectors with single photon sensitivity. Horizontal sections up to 5 x 5 mm² are obtained by galvoscanning and piezo-driven optics. Additional add-on modules for two-photon FLIM and two-photon microendoscopy are available.
- Wavelength Range: 710 - 920 nm
- In-Situ Laser Power: 2 - 50 mW
Major clinical in vivo applications include early diagnosis of skin cancer and dermatitis as well as surgery guidance e.g. in melanoma and brain surgery. Multiphoton biopsies are obtained non-invasively and label-free with detailed information on living cells and tissue structures within seconds.
Long-term intratissue drug monitoring under physiological conditions for the evaluation of pharmaceutics and cosmetics such as anti-ageing products have been performed on thousands of volunteers.
Multiphoton tomographs have been used to test the biosafety of sunscreen nanoparticles and to determine the skin age index of astronauts after exposure to UV and ionizing radiation.
The tomographs with their flexible patented scan heads and microendoscopes have been employed for small animal research e.g. neuron imaging in brain and spinal cord as well as stem cell tracking in transgenic mice.
Cell biologists are using them for inverted and upright imaging of cell cultures.
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